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lüll Pharmacologic management of herpes zoster and postherpetic neuralgia Mamdani FSCan Fam Physician 1994[Feb]; 40 (ä): 321-6, 329-32Herpes zoster is an infection caused by reactivation of dormant varicella-zoster virus. The acute course of herpes zoster is generally benign; however, some patients will experience postherpetic neuralgia characterized by severe, relentless, and at times disabling pain that is often refractory to treatment. While herpes zoster responds to acyclovir, cost-benefit considerations limit the drug's usefulness to only a select group. Postherpetic neuralgia requires a holistic approach, including pharmacologic therapy using several different classes of drugs.|*Algorithms[MESH]|Acyclovir/economics/therapeutic use[MESH]|Adrenal Cortex Hormones/therapeutic use[MESH]|Analgesics/therapeutic use[MESH]|Anticonvulsants/therapeutic use[MESH]|Antidepressive Agents, Tricyclic/therapeutic use[MESH]|Antipsychotic Agents/therapeutic use[MESH]|Cimetidine/therapeutic use[MESH]|Clinical Protocols[MESH]|Drug Costs[MESH]|Drug Therapy, Combination[MESH]|Herpes Zoster/*complications/*drug therapy/epidemiology[MESH]|Humans[MESH]|Neuralgia/*drug therapy/epidemiology/*microbiology[MESH] |