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lüll The clinical use of desflurane Eger EIYale J Biol Med 1993[Sep]; 66 (5): 491-500Desflurane, a newly introduced potent, inhaled anesthetic, differs from its predecessors in having a lower solubility in blood and tissues. The lower solubility imparts a greater control to the maintenance of anesthesia and a more rapid elimination and recovery from anesthesia. In other respects, the pharmacological properties of desflurane resemble those of its sister anesthetic, isoflurane, currently the most widely-used potent anesthetic in this and other countries. The qualitative exceptions to this resemblence are that desflurane is more pungent and produces a greater increase in heart rate, particularly at deeper levels of anesthesia.|Anesthesia, Inhalation[MESH]|Anesthetics/pharmacokinetics/*standards[MESH]|Desflurane[MESH]|Humans[MESH]|Isoflurane/*analogs & derivatives/pharmacokinetics/standards[MESH] |