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Why do class I MHC molecules bind smaller peptides than class II MHC molecules?Blanden RVImmunol Cell Biol 1995[Feb]; 73 (1): 95-7This article attempts to assemble theoretical-teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self-non-self discrimination. I propose that the small size of most class I-binding peptides precludes the production of 'MHC-restricted' antibodies. Such a strategy avoids the possibility of antibodies binding to the epitopes recognized by CD8+ T cells, thus blocking effector function required for clearance of potentially lethal infections.|Animals[MESH]|Histocompatibility Antigens Class I/*metabolism[MESH]|Histocompatibility Antigens Class II/*metabolism[MESH]|Peptides/*chemistry/*immunology[MESH]|Protein Binding/immunology[MESH] |
