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Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines Sozzani S; Locati M; Zhou D; Rieppi M; Luini W; Lamorte G; Bianchi G; Polentarutti N; Allavena P; Mantovani AJ Leukoc Biol 1995[May]; 57 (5): 788-94Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of C-C chemokines, monocyte chemotactic protein-1 (MCP-1), MCP-2, and MCP-3, in particular, encompasses, in addition to monocytes, other leukocyte populations. Evidence is presented that MCP-1, MCP-2, and MCP-3 are active on natural killer cells. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. A better understanding of signaling mechanisms will provide a new basis for therapeutic strategies.|*Signal Transduction[MESH]|Calcium/physiology[MESH]|Chemokine CCL2[MESH]|Chemotactic Factors/*physiology[MESH]|Chemotaxis[MESH]|Cytokines/*physiology[MESH]|Humans[MESH]|Monocytes/physiology[MESH]|Receptors, Cytokine/*physiology[MESH]|Recombinant Proteins[MESH] |
