Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The effects of cancer chemotherapeutic agents on normal hematopoietic precursor cells: a review Marsh JCCancer Res 1976[Jun]; 36 (6): 1853-82The effects of antineoplastic agents, singly or in combination, on normal hematopoietic precursor cells have been reviewed. Following a description of the assays used (e.g., spleen colony, in vitro colony, repopulating ability), the dose response and/or time response for each drug are presented by species and by assay as available. The schedule of drug administration, the time of the assay, and the proliferative state of the target population are the most important determinants. Alkylating agents, antitumor antibiotics, and 5-fluorouracil have exponential dose survival curves. "Phase-specific" agents such as antimetabolites, Vinca alkaloids, and ribonucleotide reductase inhibitors have plateaus in their dose survival curves, although the level of this plateau is different for different agents. Most drugs are more effective against rapidly proliferating cells although busulfan is less effective. Direct interspecies comparisons are possible with some of the clonogenic assays, which may allow prediction of the magnitude of human hematological toxicity for new agents or combinations.|Alkylating Agents/pharmacology[MESH]|Animals[MESH]|Antibiotics, Antineoplastic/pharmacology[MESH]|Antimetabolites, Antineoplastic/pharmacology[MESH]|Antineoplastic Agents/*pharmacology[MESH]|Asparaginase/pharmacology[MESH]|Benzamides/pharmacology[MESH]|Busulfan/pharmacology[MESH]|Carmustine/pharmacology[MESH]|Cisplatin/pharmacology[MESH]|Cyclophosphamide/pharmacology[MESH]|Cytarabine/pharmacology[MESH]|Drug Evaluation, Preclinical/methods[MESH]|Erythrocytes/cytology[MESH]|Fluorouracil/pharmacology[MESH]|Hematopoietic Stem Cells/*drug effects[MESH]|Humans[MESH]|Hydroxyurea/pharmacology[MESH]|Lomustine/pharmacology[MESH]|Methotrexate/pharmacology[MESH]|Nitrogen Mustard Compounds/pharmacology[MESH]|Spleen/cytology[MESH]|Vinca Alkaloids/pharmacology[MESH] |