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lüll Pfeiffer syndrome: a clinical review Moore MH; Cantrell SB; Trott JA; David DJCleft Palate Craniofac J 1995[Jan]; 32 (1): 62-70The combination of bicoronal craniosynostosis, broad thumbs and great toes, and partial variable soft tissue syndactyly of the hands and feet (i.e., Pfeiffer syndrome) classically followed a benign clinical course. A review of the clinical features of those Pfeiffer syndrome patients presenting to our unit confirm another subgroup in whom the craniofacial and associated manifestations are more extreme, with a significant risk of early demise. The early aggressive surgical management of craniostenosis, hydrocephalus, exorbitism, faciostenosis, and upper airway obstruction has provided the potential for prolonged useful survival in these cases.|Acrocephalosyndactylia/classification/*pathology/surgery[MESH]|Adult[MESH]|Airway Obstruction/pathology[MESH]|Cerebral Ventricles/abnormalities/pathology[MESH]|Child[MESH]|Eye Abnormalities/pathology[MESH]|Facial Bones/abnormalities/pathology[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Male[MESH]|Orbit/abnormalities/pathology[MESH]|Skull/abnormalities/pathology[MESH]|Treatment Outcome[MESH] |