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lüll NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction Rao AJ Leukoc Biol 1995[Apr]; 57 (4): 536-42The transcription factor NFATp (nuclear factor of activated T cells, preexisting) is likely to regulate the cyclosporin-sensitive transcription of cytokine genes and other activation-associated genes during the immune response. NFATp is the first identified member of a new family of transcription factors, whose DNA binding domains show a weak sequence similarity to those of the Rel (NF-kappa B) family of proteins. NFATp is expressed in several types of immune cells as a cytosolic protein that translocates to the nucleus following activation. The nuclear translocation is regulated by calcium and calcineurin and inhibited by cyclosporin A and FK506. In the nucleus, NFATp cooperates with Fos-Jun dimers and possibly with other transcription factors at composite elements in the regulatory regions of cytokine genes. The potential roles of NFATp and a related family member, NFATc, in cytokine gene transcription are discussed.|Amino Acid Sequence[MESH]|Animals[MESH]|Base Sequence[MESH]|Cyclosporine/*pharmacology[MESH]|Cytokines/biosynthesis/*genetics[MESH]|DNA-Binding Proteins/*physiology[MESH]|Gene Expression Regulation/*physiology[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|NFATC Transcription Factors[MESH]|Nuclear Proteins/physiology[MESH]|Phosphoproteins/physiology[MESH]|Sensitivity and Specificity[MESH]|Transcription Factors/*drug effects/*physiology[MESH]|Transcriptional Activation[MESH] |