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lüll Hematopoietic cell transplantation in fetal lambs with ceroid-lipofuscinosis Westlake VJ; Jolly RD; Jones BR; Mellor DJ; Machon R; Zanjani ED; Krivit WAm J Med Genet 1995[Jun]; 57 (2): 365-8Hematopoietic cells from the liver of normal 45-48-day-old fetal lambs (Hb type AA) were transplanted intraperitoneally into 58-60-day-old recipient fetuses (Hb type BB). The recipient fetuses resulted from mating homozygous ceroid-lipofuscinosis affected males with heterozygous, phenotypically normal, females. The sex of the donor fetus was also recorded. At age 2 1/2 months the recipient lambs with ceroid-lipofuscinosis were diagnosed by histopathology of brain biopsies. Monitoring of blood and bone marrow cells showed that an average of 9% of blood cells in ceroid-lipofuscinosis affected recipients were of donor origin. No differences were evident in the clinical course of disease, brain weight, or histopathology of organs between transplanted and non-transplanted lambs with ceroid-lipofuscinosis. Under the conditions of this experiment, transplantation of fetal hematopoietic cells was not beneficial.|*Hematopoietic Stem Cell Transplantation[MESH]|*Sheep Diseases[MESH]|Animals[MESH]|Atrophy[MESH]|Brain/pathology[MESH]|Crosses, Genetic[MESH]|Female[MESH]|Fetal Tissue Transplantation[MESH]|Fetus[MESH]|Kidney/pathology[MESH]|Liver/pathology[MESH]|Male[MESH]|Neuronal Ceroid-Lipofuscinoses/pathology/therapy/*veterinary[MESH]|Pregnancy[MESH]|Retina/pathology[MESH]|Sex Characteristics[MESH]|Sheep[MESH] |