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lüll Gamma/delta T lymphocytes in viral infections Wallace M; Malkovsky M; Carding SRJ Leukoc Biol 1995[Sep]; 58 (3): 277-83T lymphocyte progenitors differentiate into two distinct T cell lineages. Although the alpha beta and gamma delta T cell lineages resemble each other phenotypically and functionally, there are some striking differences. Some gamma delta T cells recognize, similarly to alpha beta T cells, peptides presented by major histocompatibility complex (MHC) proteins or MHC-like molecules. However, there are gamma delta T cells that recognize MHC molecules in a fundamentally different manner in comparison with alpha beta T cells. Also in contrast recognizing nonpeptide antigens. Most responses of gamma delta T cells appear to be directed against microbial pathogenic agents including bacteria, parasites, and viruses. In particular, the potent cytotoxic responses of gamma delta T cells against cells infected with, for example, herpesviruses or lentiviruses may be essential for the overall antiviral defense of vertebrates. The analysis of antiviral immunosurveillance by gamma delta T cells is crucial for understanding the unique biological role of this lymphocyte subset.|Animals[MESH]|Coxsackievirus Infections/immunology[MESH]|Enterovirus B, Human[MESH]|Herpes Simplex/immunology[MESH]|Humans[MESH]|Influenza, Human/immunology[MESH]|Mice[MESH]|Parainfluenza Virus 1, Human[MESH]|Paramyxoviridae Infections/immunology[MESH]|Receptors, Antigen, T-Cell, gamma-delta/*physiology[MESH]|T-Lymphocyte Subsets/*physiology[MESH]|Virus Diseases/*immunology[MESH] |