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lüll Leukocyte CD11/CD18 integrins: biological and clinical relevance Mazzone A; Ricevuti GHaematologica 1995[Mar]; 80 (2): 161-75The integrin family consists of a series of related alpha beta heterodimers (subunits of 95,000-200,000 Mw) involved in a variety of cell-matrix and cell-cell adhesion functions. Leukocyte adhesion has biological importance in numerous processes involving host defense. The CD11/CD18 integrins are differentiated antigens which play a critical role in this mechanism. CD11a/CD18 are apparent on early progenitors of all myeloid and erythroid cells. CD11b/CD18 and CD11c/CD18 are more restricted antigens normally expressed on monocytes, macrophages, PMN and natural killer cells. Activated granulocytes and monocytes express far more CD11b/CD18 than the other two antigens: 6 to 8 x 10(5) CD11b/CD18 molecules appear on maximally activated granulocytes. These integrins and in particular the beta 2 subunit are lacking in a genetic disease. On the other hand, they are fundamental in numerous physiological processes and in various hematological and cardiovascular diseases. The biochemical characterization and behavior of the CD11/CD18 complex in various clinical conditions are the subject of this review.|Adult[MESH]|Animals[MESH]|Antibodies, Monoclonal/therapeutic use[MESH]|CD11 Antigens/*physiology[MESH]|CD18 Antigens/*physiology[MESH]|Cell Adhesion/*physiology[MESH]|Graft Rejection/prevention & control[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Infections/immunology/pathology[MESH]|Inflammation/immunology/pathology/therapy[MESH]|Integrins/*physiology[MESH]|Intercellular Adhesion Molecule-1/physiology[MESH]|Leukocyte-Adhesion Deficiency Syndrome/immunology/pathology[MESH]|Leukocytes/*physiology[MESH]|Ligands[MESH]|Myelodysplastic Syndromes/immunology/pathology[MESH]|Neoplasm Metastasis/prevention & control[MESH]|Rabbits[MESH]|Reperfusion Injury/immunology/pathology[MESH] |