Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll CT and MR of the brain in glutaric acidemia type I: a review of 59 published cases and a report of 5 new patients Brismar J; Ozand PTAJNR Am J Neuroradiol 1995[Apr]; 16 (4): 675-83PURPOSE: To identify a pattern of findings on CT or MR of the brain in glutaric acidemia type I typical enough to permit a correct diagnosis. METHODS: Clinical history and findings and brain CT and MR results in 59 previously reported patients (MR in 12) and in 5 new patients (all examined with MR and 3 also with CT) were reviewed. RESULTS: In half the patients macrocephaly was present, and in half the onset was acute, often following infection and mimicking encephalitis. Although brain atrophy or hypoplasia was found in 61% and white matter changes in 51% of the patients, open opercula (usually very widely open) and often also wide cerebrospinal fluid spaces anterior to the temporal lobes were seen in 93%. Basal ganglia lesions, presenting as volume loss and high T2 signal in the caudate head and often also the lentiform nucleus bilaterally, were found in 44% and extracerebral fluid collections in 7 of 64 patients. CONCLUSION: The finding of very widely open opercula suggests glutaric acidemia type I, and if combined with basal ganglia lesions is almost pathognomonic, especially in a child with macrocephaly.|*Magnetic Resonance Imaging[MESH]|*Tomography, X-Ray Computed[MESH]|Atrophy[MESH]|Brain Damage, Chronic/blood/*diagnosis/genetics[MESH]|Brain Diseases, Metabolic/*diagnosis[MESH]|Brain/pathology[MESH]|Child, Preschool[MESH]|Diagnosis, Differential[MESH]|Encephalitis/blood/diagnosis[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Glutarates/*blood[MESH]|Humans[MESH]|Infant[MESH]|Male[MESH]|Metabolism, Inborn Errors/blood/*diagnosis/genetics[MESH] |