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lüll Piperacillin-tazobactam treatment for severe intra-abdominal infections Legrand JC; Bastin F; Belva P; Chastel C; Renaux J; Van Eukem PActa Chir Belg 1995[May]; 95 (3): 162-5In this limited series of 23 patients suffering from severe or life-threatening intra-abdominal infection, piperacillin + tazobactam, together with adequate surgical drainage and resections, cured 78% of our patients and eradicated almost all the pathogens. Side effects included essentially eosinophilia and elevation of transaminases but was never severe. Piperacillin + tazobactam seem thus to be an acceptable treatment, associated with correct surgical drainage. This regimen has to be compared in appropriate trial versus gold standard therapy, such as imipenem, a beta-lactam with aminoglucoside and imidazole or clindamycin or with broad spectrum beta-lactam and other inhibitors or beta-lactamases, but our rate of cure is impressive in such a population.|Abdomen/surgery[MESH]|Adult[MESH]|Aged[MESH]|Drainage[MESH]|Drug Therapy, Combination/*therapeutic use[MESH]|Eosinophilia/chemically induced[MESH]|Female[MESH]|Gram-Negative Bacterial Infections/*drug therapy/surgery[MESH]|Gram-Positive Bacterial Infections/*drug therapy/surgery[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Penicillanic Acid/administration & dosage/adverse effects/*analogs & derivatives[MESH]|Piperacillin/*administration & dosage/adverse effects[MESH]|Tazobactam[MESH]|beta-Lactamase Inhibitors[MESH] |