Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The one signal theory of B cell activation revisited: a role for surface immunoglobulin in regulating T-independent antibody responses?Mamchak AA; Hodgkin PDImmunol Cell Biol 1995[Jun]; 73 (3): 266-71Early theories of antibody production by B cells achieved considerable success in predicting B cell behaviour with simple deductive models. One such model, the one signal theory, postulated that the antigen receptor on B cells played only a passive non-signalling role in focusing non-specific activating signals to the B cell surface. This prediction is at least partially consistent with recent discoveries concerning the helper signals delivered to B cells by T cells. Here, we re-examine the foundation of this theoretical prediction with the benefit of recent information. The experimental basis for the theory was a study of B cell activation by LPS and, in particular, the interpretation of a bell-shaped dose-response curve. The logic applied is appropriate to explain some, but not all, forms of B cell behaviour because, as is now clear, the role played by the antigen signal varies depending upon the method of activation. This re-examination suggests an alternative interpretation of the LPS-induced bell-shaped curves that incorporates a role for an antigen signal. If correct, the mechanism would ensure that T-independent responses are drawn from low affinity precursors.|*Lymphocyte Activation[MESH]|Animals[MESH]|Antibody Formation[MESH]|Antigens, T-Independent/*immunology[MESH]|B-Lymphocytes/*immunology[MESH]|Receptors, Antigen, B-Cell/*physiology[MESH]|Signal Transduction/*immunology[MESH] |