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lüll Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease) Lundgren AL; Lindberg R; Ludwig H; Gosztonyi GActa Neuropathol 1995[]; 90 (2): 184-93The inflammatory cell composition and the expression of major histocompatibility complex (MHC) antigens in the central nervous system (CNS) of 13 cats with a spontaneous, Borna disease-like meningoencephalomyelitis (staggering disease) was investigated by immunohistochemistry with a panel of monoclonal and polyclonal antibodies. T lymphocytes were the predominating inflammatory cells within the adventitial space. CD4+ T cells were more abundant than CD8+ T cells. Scattered IgG-, IgA- and IgM-containing cells were found in the adventitial space and surrounding neuropil, often adjacent to neurons. There was a markedly increased MHC class II expression in cells morphologically resembling microglia. In several cats, Borna disease virus specific antigen was detected, but only in a few cells, mainly of macrophage character. Our findings indicate a long-standing inflammatory reaction in the CNS of cats with staggering disease, possibly triggered and sustained by a persistent viral infection.|Animals[MESH]|Antibodies, Monoclonal/immunology[MESH]|Borna Disease/*pathology[MESH]|Cats[MESH]|Central Nervous System/*immunology/*pathology[MESH]|Female[MESH]|Immunoglobulins[MESH]|Immunohistochemistry[MESH]|Lymphocytes/immunology[MESH]|Male[MESH]|Meningoencephalitis/*pathology[MESH] |