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lüll La cefamandole comme antibiotique phophylactique en chirurgie abdominale Etude comparee cefamandole versus clindamycine/tobramycine Iarchy JActa Chir Belg 1980[Sep]; 79 (5): 321-6A prospective, randomized and controlled study of prophylactic A.B. was made in 100 patients prior to abdominal surgery. Fifty patients received 3 x 2 g of cefamandole I.V. within 24 hrs, the first dose being given at the time of anesthetic induction. Postoperative infections occurred in 2% of this group. Fifty patients received the association Clindamycin-Tobramycin (clindamycin 600 mg - tobramycin 80 mg/8 hrs) for 24 hrs, the first dose also at the induction of anesthesia. The complication rate in this group was 18%. The difference between those 2 groups is statistically significant (p less than 0.01). Cefamandole used as a prophylactic antibiotic in abdominal surgery reduces the incidence of postoperative wound infections when compared to the association clindamycin-tobramycin.|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Anti-Bacterial Agents/*therapeutic use[MESH]|Cefamandole/*therapeutic use[MESH]|Cephalosporins/*therapeutic use[MESH]|Clindamycin/*therapeutic use[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Prospective Studies[MESH]|Random Allocation[MESH]|Surgical Wound Infection/*prevention & control[MESH]|Tobramycin/*therapeutic use[MESH] |