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The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation Benner R; Hijmans W; Haaijman JJClin Exp Immunol 1981[Oct]; 46 (1): 1-8Immunoglobulin (Ig) secreting cells occur in all lymphoid tissues, including the bone marrow (BM). There are important differences between the various organs with respect to their number of Ig-secreting cells and the heavy chain isotype distribution of the secreted Igs. Furthermore, both distribution patterns depend on age. Early in life most Ig-secreting cells are localized in spleen and lymph nodes. In adults, however, the majority of all Ig-secreting cells of the individual are localized in the BM. Immunization can lead to the appearance of substantial numbers of antibody-forming cells in BM. The kinetics of the BM response are different from the response in the peripheral lymphoid tissues. Shortly after immunization most antibody-forming cells occur in the peripheral lymphoid tissues, but later on, especially during secondary type responses, most antibody-forming cells are localized in the BM. Apparently, antibody formation is regulated in such a way that peripheral lymphoid tissues respond rapidly, but only for a short period, whereas the BM response starts slowly, but takes care of a long-lasting massive production of antibodies to antigens which repeatedly challenge the organism.|*Antibody Formation[MESH]|Age Factors[MESH]|Animals[MESH]|Antibody-Producing Cells/metabolism[MESH]|Bone Marrow/*immunology[MESH]|Hemolytic Plaque Technique[MESH]|Humans[MESH]|Immunization[MESH]|Immunoglobulins/*biosynthesis[MESH]|Mice[MESH]|Mice, Inbred Strains[MESH]|Rabbits[MESH]|Time Factors[MESH] |
