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lüll Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non-steroid mild analgesics Higgs GABr J Clin Pharmacol 1980[Oct]; 10 Suppl 2 (Suppl 2): 233S-235S1 Cyclo-oxygenase products such as prostaglandins of the E series and prostacyclin produce the hyperalgesia associated with inflammation. 2 These substances may cause pain and incapacity in some inflammatory conditions. 3 Prostaglandin E2 sensitizes the chemical receptors of afferent pain endings to other inflammatory mediators such as bradykinin and histamine. 4 Unstable intermediates formed in the generation of prostaglandins may also play a role in the production of pain. 5 Drugs such as indomethacin and aspirin which are potent inhibitors of prostaglandin biosynthesis may exert their analgesic effect through this mechanism.|Analgesics/*pharmacology[MESH]|Arachidonic Acids/*metabolism[MESH]|Aspirin/pharmacology[MESH]|Epoprostenol/physiology[MESH]|Humans[MESH]|Hyperalgesia/*metabolism[MESH]|Hyperesthesia/*metabolism[MESH]|Pain/*metabolism[MESH]|Prostaglandins/physiology[MESH] |