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Reye s syndrome: a clinical review Crocker JF; Bagnell PCCan Med Assoc J 1981[Feb]; 124 (4): 375-82, 425Reye's syndrome is a virus-associated biphasic disease that causes acute encephalopathy in infants and children. Epidemiologic and experimental data support the hypothesis that it is a multifactorial disease of modern civilization. Just as young patients seem to be recovering uneventfully from the first phase of the illness, usually a nonspecific viral-like illness such as a respiratory tract infection or gastroenteritis, the second phase, encephalopathy, starts unexpectedly, with vomiting and sensorial changes. Identifying the syndrome early ;in the second phase and referring the child to a specialized centre with the experience, staff and facilities to manage this phase has improved the numbers and neurologic condition of survivors, though the overall mortality is still about 20%. Therapy is primarily directed at facilitating adequate cerebral perfusion pressure.|*Reye Syndrome/diagnosis/etiology/therapy[MESH]|Adolescent[MESH]|Child[MESH]|Child, Preschool[MESH]|Diagnosis, Differential[MESH]|Humans[MESH]|Intracranial Pressure/drug effects[MESH]|Mannitol/pharmacology/therapeutic use[MESH]|Prognosis[MESH] |
