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lüll Selective expression of the common acute lymphoblastic leukemia (gp 100) antigen on immature lymphoid cells and their malignant counterparts Greaves MF; Hariri G; Newman RA; Sutherland DR; Ritter MA; Ritz JBlood 1983[Apr]; 61 (4): 628-39The selectivity of monoclonal antibody J-5 (anti-gp 100, common ALL antigen) for normal and leukemic hemopoietic cells has been investigated. J-5 gave concordant reactions with rabbit anti-cALL, coredistributed on the cell surface, and precipitated a similar if not identical glycoprotein from leukemic and normal tissue. Normal, immature lymphoid cells reactive with J-5 were detected in bone marrow and in fetal thymus. In marrow they were largely coincident with the TdT+ population. J-5 defines a major subgroup of ALL (common ALL) with a favorable prognosis. Of 853 non-ALL acute leukemias investigated, 80 were J-5 positive. These included 14 cases diagnosed as AML, 51 TdT+ blast crises of CGL, and 15 cases diagnosed as "AUL." Of the 14 J-5+ AML, 13 were subsequently rediagnosed either as cALL (10 cases) or mixed lymphoid-myeloid leukemias (3 cases). One-hundred forty-three cases of mature lymphoid cell leukemia (91 B, 52 T) were investigated with J-5; 3 cases only, of disseminated B lymphoma, were positive, albeit weakly. A higher proportion of follicular lymphomas are, however, J-5 positive when studied in sections of biopsy material. A similar pattern of selective reactivity was observed in a series of leukemia/lymphoma cell lines. These studies emphasize the diagnostic value of monoclonal anti-cALL reagents.|Animals[MESH]|Antibodies, Monoclonal/immunology[MESH]|Antibodies, Neoplasm/immunology[MESH]|Antigen-Antibody Reactions[MESH]|Antigens, Neoplasm/*immunology[MESH]|Cell Line[MESH]|Fluorescent Antibody Technique[MESH]|Humans[MESH]|Leukemia, Experimental[MESH]|Leukemia, Lymphoid/*immunology/pathology[MESH]|Lymphocytes/*immunology[MESH]|Lymphoma/immunology[MESH]|Rabbits/immunology[MESH]|Thymus Neoplasms/immunology[MESH] |