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lüll Antigen-specific T-cell factors Taussig MJImmunology 1980[Dec]; 41 (4): 759-87Antigen-specific T-cell factors are mediator molecules which are produced by helper and suppressor T cells and which can perform the function of those cells in an antigen-specific manner. They probably play an important part in immunoregulation. The major histocompatibility complex has a controlling influence on their structure and activity, while their antigen-recognition properties may be conferred by immunoglobulin V regions. Interest in the factors derives from three related areas of research, namely (i) the problem of T-cell recognition of antigen; (ii) the mechanisms of cellular interactions in antibody production and cell-mediated immunity; and (iii) the genetic control of immune responses. This review discusses the literature up to June 1980 on their production, structure, genetic restriction and mechanism of action.|*Epitopes/analysis/genetics[MESH]|Animals[MESH]|Cell Line[MESH]|Genes, MHC Class II[MESH]|Humans[MESH]|Hybrid Cells[MESH]|Immunoassay/methods[MESH]|Immunoglobulin Variable Region/immunology[MESH]|Major Histocompatibility Complex[MESH]|Mice[MESH]|Models, Genetic[MESH]|Rabbits[MESH]|Rats[MESH]|Structure-Activity Relationship[MESH]|T-Lymphocytes, Regulatory/immunology[MESH]|T-Lymphocytes/*immunology[MESH] |