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Chemical structure and properties of midazolam compared with other benzodiazepines Gerecke MBr J Clin Pharmacol 1983[]; 16 Suppl 1 (Suppl 1): 11S-16SA short review is given of the basic chemical development in the field of 'classical' and 'annelated' benzodiazepines, distinguishing between pro-drugs and directly acting compounds. Some properties of midazolam that are of special interest for its practical use are discussed, such as: the basicity of its imidazole ring nitrogen, which allows water-soluble salts and well-tolerated aqueous injectable solutions to be prepared; its stability to hydrolytic degradation; its rapid metabolic inactivation, which is mainly determined by the methyl group on the imidazole ring, and which is much faster than that of classical benzodiazepines.|*Anti-Anxiety Agents/metabolism[MESH]|*Benzodiazepines/metabolism[MESH]|Animals[MESH]|Chemical Phenomena[MESH]|Chemistry[MESH]|Humans[MESH]|Midazolam[MESH]|Receptors, Cell Surface/metabolism[MESH]|Receptors, GABA-A[MESH]|Structure-Activity Relationship[MESH] |
