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Hodgkin s disease and other malignant lymphomas Rosenberg SA; Kaplan HSCalif Med 1970[Oct]; 113 (4): 23-38Systematic studies of the patterns of anatomic distribution, pathways of probable spread, and prognosis of the malignant lymphomas have been greatly aided by the development of new histopathologic classifications and the introduction of more sophisticated and precise diagnostic techniques, such as lymphangiography and laparotomy with splenectomy and retroperitoneal node biopsy. Concomitantly, megavoltage radiotherapy apparatus has made total-lymphoid radiotherapy feasible and practical, and the availability of a widening spectrum of chemotherapeutic agents has ushered in a new era of combination chemotherapy. Collectively, these diagnostic and therapeutic advances have already begun to yield a dramatic improvement in the prognosis of Hodgkin's disease and the other malignant lymphomas.|*Hodgkin Disease/complications/diagnosis/drug therapy/pathology/radiotherapy[MESH]|*Lymphoma/classification/drug therapy/radiotherapy[MESH]|Adrenal Cortex Hormones/therapeutic use[MESH]|Alkylating Agents/therapeutic use[MESH]|Benzoates/therapeutic use[MESH]|Biopsy[MESH]|Humans[MESH]|Lymph Nodes/diagnostic imaging[MESH]|Neoplasm Metastasis[MESH]|Radiography[MESH]|Radiotherapy, High-Energy[MESH]|Splenectomy[MESH]|Time Factors[MESH]|Vinblastine/therapeutic use[MESH]|Vincristine/therapeutic use[MESH] |