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English Wikipedia
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Recent advances in the immunopathogenesis of systemic lupus erythematosus Bardana EJ Jr; Pirofsky BWest J Med 1975[Feb]; 122 (2): 130-44Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disease having definite etiologic associations with ethnic, genetic, viral and immunologic factors. Its pathologic hallmark, vasculitis, is currently felt to be the end result of an immune-complex mechanism. Several clinical and serologic variants of SLE are recognized including discoid lupus erythematosus (DLE), mixed connective tissue disease (MCTD) and drug-induced equivalents-such as procainamide-induced lupus (PIL). The distinguishing features of these variants as well as their prognosis and therapy are discussed in relation to recent developments in the immunopathogenesis of SLE.|*Lupus Erythematosus, Systemic/immunology[MESH]|Animals[MESH]|Antibodies, Viral/analysis[MESH]|Antigen-Antibody Complex[MESH]|Black People[MESH]|Chronic Disease[MESH]|Diagnosis, Differential[MESH]|Dogs[MESH]|Epitopes[MESH]|Female[MESH]|Histocompatibility Antigens[MESH]|Humans[MESH]|Lupus Erythematosus, Discoid/diagnosis[MESH]|Male[MESH]|Prognosis[MESH]|Sex Factors[MESH]|White People[MESH] |
