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Biological function of gamma E antibodies and mechanisms of reaginic hypersensitivity Ishizaka K; Ishizaka TClin Exp Immunol 1970[Jan]; 6 (1): 25-42Human reaginic antibodies in sera of atopic individuals are associated with immunoglublin E which represents a distinct immunoglobulin class. The gammaE antibody agglutinated red cells coated with antigen, indicating that the antibodies are probably divalent. However, the antibodies do not have complement-fixing activity. The antibodies are responsible for P-K reactions in humans, passive cutaneous anaphylaxis reactions in monkeys and sensitize human leucocytes and monkey lung tissues, but not the guinea-pig skin. Immunoglobulin E combines with the tissues which are involved in the reaginic hypersensitivity reactions through the Fc portion of the molecules. The initial step in hypersensitivity reactions is probably bridging of cell-bound gammaE molecules which induce structural changes in these molecules. These changes may induce enzymatic sequences leading to the release of histamine and/or slow reacting substance of anaphylaxis depending on the cells involved. Studies on the distribution of gammaE forming cells indicated that these cells localized in respiratory and gastro-intestinal tracts. The results suggested that locally formed gammaE may play an important role in allergic diseases.|*Antibodies[MESH]|*Hypersensitivity, Immediate[MESH]|*gamma-Globulins/analysis/biosynthesis[MESH]|Animals[MESH]|Antigen-Antibody Reactions[MESH]|Antigens/analysis[MESH]|Autacoids[MESH]|Chromatography[MESH]|Guinea Pigs[MESH]|Haplorhini[MESH]|Histamine Release[MESH]|Humans[MESH]|Immunochemistry[MESH]|Immunodiffusion[MESH]|Immunoelectrophoresis[MESH]|Immunoglobulin E[MESH]|Leukocytes/immunology[MESH]|Lymphoid Tissue/immunology[MESH]|Molecular Weight[MESH]|Passive Cutaneous Anaphylaxis[MESH]|Rabbits[MESH]|Skin Tests[MESH] |
