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lüll Pharmacokinetics and metabolism of various benzodiazepines used as hypnotics Breimer DDBr J Clin Pharmacol 1979[]; 8 (1): 7S-13S1 In the management of insomnia with drugs, any action should be restricted to the duration of the night and residual effects should be absent during the day-time. The intermittent type of drug action desired is fundamentally different from drug treatment where a constant effect is sought. 2 Duration of drug action is dependent on the kinetics of distribution and elimination of the parent drug and its effective metabolites. In addition biopharmaceutical factors, such as those which promote a rapid rate of absorption, are important. 3 These considerations serve as a guide for a review of the kinetics and metabolism of various benzodiazepines.|Anti-Anxiety Agents/*metabolism[MESH]|Benzodiazepines[MESH]|Half-Life[MESH]|Humans[MESH]|Hypnotics and Sedatives/*metabolism[MESH]|Kinetics[MESH]|Time Factors[MESH] |