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Aspirin-sensitive asthma Slepian IK; Mathews KP; McLean JAChest 1985[Mar]; 87 (3): 386-91Aspirin intolerance is particularly common in asthmatic patients who additionally have chronic rhinitis and/or nasal polyps. These individuals differ in several respects from patients who experience urticaria and/or angioedema after aspirin administration, and differing mechanisms may be involved. Data regarding the latter are indirect and incomplete, but suggest that ASA-sensitive asthma is most likely to be related in some manner to the capacity of ASA to inhibit cyclooxygenases, enhanced lipoxygenase metabolism perhaps playing a crucial role. Current research employing ASA "desensitization" may help to elucidate these enigmas.|Arachidonic Acid[MESH]|Arachidonic Acids/metabolism[MESH]|Aspirin/administration & dosage/*adverse effects[MESH]|Asthma/chemically induced/*immunology/metabolism[MESH]|Desensitization, Immunologic[MESH]|Drug Hypersensitivity/etiology/*metabolism[MESH]|Humans[MESH]|Prostaglandin Antagonists[MESH] |
