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lüll Chlamydia trachomatis: in vitro susceptibility to antibiotics singly and in combination Christensen JJ; Holten-Andersen W; Nielsen PBActa Pathol Microbiol Immunol Scand B 1986[Oct]; 94 (5): 329-32Decreased susceptibility in vitro to erythromycin has been demonstrated for few C. trachomatis isolates outside Scandinavia, making local susceptibility-screening indicated. Eleven recent isolates of C. trachomatis found in a Danish hospital have been examined for susceptibility, expressed as minimal inhibitory concentration (MIC) to antibacterial agents commonly used in genito-urinary infections. Full susceptibility to doxycycline and erythromycin was demonstrated. Clindamycin and ampicillin showed moderate activity, and sulfamethizole had a MIC value in the border area of what is needed for therapeutic effect in non-urinary infections. C. trachomatis, being a major pathogen in pelvic inflammatory disease, makes combination chemotherapy desirable in order to protect against resistance development, to obtain synergistic effect and to ensure effect in infections of mixed etiology - provided antagonism could not be anticipated. In three checkerboard trials, with the combinations doxycycline plus ampicillin, erythromycin plus sulfamethizole and ampicillin plus sulfamethizole, using MIC as end-point, neither synergism nor antagonism could be demonstrated in the concentration range from 1/8 to 4 times the MIC values of each drug.|Ampicillin/pharmacology[MESH]|Anti-Bacterial Agents/*pharmacology[MESH]|Chlamydia trachomatis/*drug effects[MESH]|Clindamycin/pharmacology[MESH]|Doxycycline/pharmacology[MESH]|Drug Combinations[MESH]|Erythromycin/pharmacology[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Microbial Sensitivity Tests[MESH]|Sulfamethizole/pharmacology[MESH] |