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Kinetics of cell kill by hyperthermia Bhuyan BKCancer Res 1979[Jun]; 39 (6 Pt 2): 2277-84A review of published reports showed that there was surprisingly good agreement between different authors on the heat sensitivity of a particular cell line. For several cell lines, there was a marked difference in the heat of inactivation above 43 degrees (deltaH = 148 kcal/mol) and below 43 degrees (deltaH = 365 kcal/mol). This may indicate different mechanisms of cell killing above and below this temperature. With all cell lines tested, M- and S-phase cells were much more heat sensitive than were G1 or G2 cells. The heat sensitivity of S-phase cells is in contrast to the resistance of these cells to X-rays. The effect of hyperthermia on cell progression is discussed. The possibility of greater sensitivity of neoplastic cells to hyperthermia as compared to normal cells seems very promising.|*Cell Survival/drug effects[MESH]|Animals[MESH]|Antineoplastic Agents/administration & dosage[MESH]|Cell Cycle[MESH]|Cell Line[MESH]|Cricetinae[MESH]|Doxorubicin/administration & dosage[MESH]|HeLa Cells[MESH]|Hot Temperature/*therapeutic use[MESH]|Kinetics[MESH]|Leukemia L1210/therapy[MESH]|Mammary Neoplasms, Experimental/therapy[MESH]|Mice[MESH]|Neoplasms, Experimental/*therapy[MESH] |
