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The electrocardiogram in the assessment of the effect of drugs on cardiac arrhythmias Reid DSBr J Clin Pharmacol 1978[Dec]; 6 (6): 473-85The search for the ideal antiarrhythmic drug continues since none of the available agents offers optimum antiarrhythmic therapy. The continuing search coupled with the interest in the mechanisms of cardiac arrhythmias has led to the development of new techniques for the study of arrhythmias and antiarrhythmic drugs. In this article it is proposed to discuss the electrocardiographic methods used in the assessment of antiarrhythmic drugs. Firstly, to discuss the electrocardiogram in the assessment of the clinical electrophysiological properties of a drug and secondly, the electrocardiogram in the assessment of the value of the drug in the management of cardiac arrhythmias in man.|*Electrocardiography[MESH]|Arrhythmias, Cardiac/drug therapy/*physiopathology[MESH]|Bundle of His/drug effects[MESH]|Electric Stimulation[MESH]|Heart Conduction System/drug effects[MESH]|Humans[MESH]|Physical Exertion[MESH]|Time Factors[MESH] |
