Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Antibiotic penetration into the infected knee A rabbit experiment Frimodt-Moller N; Riegels-Nielsen PActa Orthop Scand 1987[Jun]; 58 (3): 256-9We investigated the diffusion of penicillin-G, cloxacillin, clindamycin, and netilmicin into synovial fluid and membrane in rabbits. Purulent arthritis was induced in the right knee of each rabbit by inoculation of Staphylococcus aureus phage type 3C, whereas sterile saline was injected into the left knee to serve as a control. Two days later, concentrations of antibiotics were determined in serum, synovial fluid, and membrane after an intramuscular single dose. All four drugs diffused readily into infected joints, whereas the corresponding concentrations in the normal joints were 2-3 times lower. Clindamycin showed the highest intraarticular penetration, cloxacillin the lowest. The lower penetration of cloxacillin corresponded to its higher protein binding in rabbit serum. Considering the sufficient local concentrations achieved, parenteral treatment obviates the need for local instillation of these antibiotics.|Animals[MESH]|Anti-Bacterial Agents/administration & dosage/*metabolism[MESH]|Arthritis, Infectious/blood/*metabolism[MESH]|Clindamycin/blood/metabolism[MESH]|Cloxacillin/blood/metabolism[MESH]|Injections, Intra-Articular[MESH]|Injections, Intramuscular[MESH]|Knee Joint/*metabolism[MESH]|Netilmicin/blood/metabolism[MESH]|Penicillins/blood/metabolism[MESH]|Rabbits[MESH]|Staphylococcal Infections/blood/*metabolism[MESH]|Synovial Fluid/metabolism[MESH]|Synovial Membrane/metabolism[MESH] |