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lüll Specificity of arrest, survival, and growth of selected metastatic variant cell lines Nicolson GL; Brunson KW; Fidler IJCancer Res 1978[Nov]; 38 (11 Pt 2): 4105-11Animal tumor models for blood-borne metastasis have been developed by in vitro cloning or in vivo selection of malignant tumor cell populations to obtain organ-preferring variant tumor cell lines with altered arrest, survival, invasion, and growth properties. Selection and some tumor cell characteristics of lung-, brain-, and ovary-colonizing metastatic B16 melanoma, liver-colonizing RAW114 lymphosarcoma, and lung-colonizing MSV3T3 vasoformative sarcoma variant lines will be discussed along with additional data, suggesting that tumor cells of varying malignant potential preeexist in the unselected tumor population.|*Neoplasm Metastasis[MESH]|*Neoplastic Cells, Circulating[MESH]|Animals[MESH]|Brain Neoplasms/pathology[MESH]|Cell Division[MESH]|Cell Line[MESH]|Cell Membrane/pathology[MESH]|Cell Survival[MESH]|Cytotoxicity, Immunologic[MESH]|Disease Models, Animal[MESH]|Female[MESH]|Liver Neoplasms/pathology[MESH]|Lung Neoplasms/pathology[MESH]|Lymphocytes/immunology[MESH]|Melanoma/immunology/pathology[MESH]|Mice[MESH]|Neoplasms, Experimental/blood/immunology/*pathology[MESH]|Ovarian Neoplasms/pathology[MESH]|Sarcoma, Experimental/pathology[MESH] |