Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Association of alpha 1-antitrypsin deficiency with lung and liver diseases Resendes MWest J Med 1987[Jul]; 147 (1): 48-53alpha(1)-Protease inhibitor (alpha(1)-Pi) deficiency is associated with emphysema, neonatal hepatitis and cirrhosis. The deficiency associated with emphysema has multiple alleles. Cigarette smoke may influence the onset of emphysema in a twofold manner: by overwhelming the concentration of alpha(1)-Pi by increasing elastase release, and by inactivating the alpha(1)-Pi active site through oxidation. alpha(1)-Pi-associated hepatic disease occurs primarily in children with the allele PiZZ, most of whom are asymptomatic although in a small percentage severe obstructive jaundice and fatal junvenile cirrhosis develop. Pharmacologic intervention and alpha(1)-Pi replacement therapy are being tested against alpha(1)-Pi-associated emphysema.|*alpha 1-Antitrypsin Deficiency[MESH]|Adult[MESH]|Child[MESH]|Child, Preschool[MESH]|Hepatitis/etiology/genetics[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Liver Cirrhosis/etiology/genetics[MESH]|Liver Diseases/*etiology[MESH]|Lung Diseases/*etiology[MESH]|Middle Aged[MESH]|Pulmonary Emphysema/etiology/genetics[MESH]|Smoking/adverse effects[MESH] |