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Role of thymidine in biochemical modulation: a review O'Dwyer PJ; King SA; Hoth DF; Leyland-Jones BCancer Res 1987[Aug]; 47 (15): 3911-9The role of thymidine in the treatment of cancer has been under clinical investigation for nearly a decade. Clinical trials have demonstrated that it lacks antitumor activity in its own right. In this review, the mechanism of action and rationale for the use of thymidine as a biochemical modulator of standard agents such as 5-fluorouracil, 1-beta-D-arabinofuranosylcytosine, and methotrexate are summarized. With this background, the clinical trials which have been conducted with thymidine, either alone or in combination, are described. We suggest a number of further studies of the role of thymidine in the biochemical modulation of antimetabolites.|Animals[MESH]|Antimetabolites, Antineoplastic/administration & dosage/metabolism/*pharmacology[MESH]|Antineoplastic Combined Chemotherapy Protocols/pharmacology/therapeutic use[MESH]|Aspartic Acid/administration & dosage/analogs & derivatives/pharmacology[MESH]|Cytarabine/administration & dosage/metabolism[MESH]|DNA Replication/drug effects[MESH]|DNA, Neoplasm/biosynthesis[MESH]|Deoxycytidine Kinase/antagonists & inhibitors[MESH]|Drug Evaluation[MESH]|Drug Synergism[MESH]|Fluorouracil/administration & dosage/metabolism[MESH]|Folic Acid Antagonists[MESH]|Humans[MESH]|Interphase/drug effects[MESH]|Kinetics[MESH]|Leukemia/drug therapy[MESH]|Methotrexate/administration & dosage/pharmacology[MESH]|Mice[MESH]|Neoplasms, Experimental/drug therapy/metabolism[MESH]|Neoplasms/*drug therapy/metabolism[MESH]|Nucleic Acid Synthesis Inhibitors[MESH]|Nucleotides/metabolism[MESH]|Phosphonoacetic Acid/administration & dosage/analogs & derivatives/pharmacology[MESH]|RNA, Neoplasm/biosynthesis[MESH]|Species Specificity[MESH]|Thymidine/administration & dosage/adverse effects/metabolism/*pharmacology[MESH] |
