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Important risk factors of allograft survival in cadaveric renal transplantation A study of 426 patients Diethelm AG; Blackstone EH; Naftel DC; Hudson SL; Barber WH; Deierhoi MH; Barger BO; Curtis JJ; Luke RGAnn Surg 1988[May]; 207 (5): 538-48Multiple risk factors contribute to the allograft survival of patients who have cadaveric renal transplantation. A retrospective review of 19 such factors in 426 patients identified race, DR match, B + DR match, number of transplants, and preservation time to have a significant influence. The parametric analysis confirmed the effect to be primarily in the early phase, i.e., first 6 months. All patients received cyclosporine with other methods of immunosuppression resulting in an overall 1-year graft survival rate of 66%. The overall 1-year graft survival rate in the white race was 73% and in the black race was 57% (p = 0.002). Allograft survival and DR match showed white recipients with a 1 DR match to have 75% survival at 1 year compared with 57% in the black patient (p = 0.009). If HLA B + DR match was considered, the white recipient allograft survival increased to 76%, 84%, and 88% for 1, 2, and 3 match kidneys by parametric analysis. Patients receiving first grafts had better graft survival (68%) than those undergoing retransplantation (58%) (p = 0.05). Organ preservation less than 12 hours influenced allograft survival with a 78% 1-year survival rate compared with 63% for kidneys with 12-18 hours of preservation. Despite the benefits of B + DR typing, short preservation time, and first transplants to the white recipient, the allograft survival in the black recipient remained uninfluenced by these parameters.|*Graft Survival[MESH]|*Kidney Transplantation[MESH]|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Antibodies, Monoclonal/therapeutic use[MESH]|Black People[MESH]|Cadaver[MESH]|Child[MESH]|Female[MESH]|Graft Rejection[MESH]|HLA Antigens/analysis[MESH]|HLA-B Antigens[MESH]|HLA-DR Antigens/analysis[MESH]|Histocompatibility Testing[MESH]|Humans[MESH]|Immunosuppression Therapy/methods[MESH]|Kidney/immunology[MESH]|Male[MESH]|Middle Aged[MESH]|Organ Preservation[MESH]|Risk Factors[MESH]|Time Factors[MESH]|Transplantation, Homologous[MESH]|White People[MESH] |
