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lüll Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications Guo Z; Jiang N; Moore J; McCoy CP; Ziminska M; Rafferty C; Sarri G; Hamilton AR; Li Y; Zhang L; Zhu S; Sun DACS Appl Mater Interfaces 2019[Jul]; 11 (30): 27269-27278Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.|*Tissue Engineering[MESH]|Bone Neoplasms/*drug therapy[MESH]|Chitosan/*chemistry[MESH]|Coated Materials, Biocompatible/chemical synthesis/*chemistry/therapeutic use[MESH]|Drug Liberation/drug effects[MESH]|Durapatite/chemistry[MESH]|Graphite/chemistry[MESH]|Humans[MESH]|Hydrogen-Ion Concentration[MESH]|Phototherapy[MESH]|Porosity[MESH]|Tissue Scaffolds/chemistry[MESH] |