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lüll Renal Oncocytoma Williams GM; Lynch DTStatPearls-/-ä 2024[Jan]; ä (ä): äRenal oncocytomas are common benign kidney neoplasms that account for 3% to 7% of all renal neoplasms. They usually occur in adults, most frequently in the seventh decade of life. Renal oncocytomas may be discovered incidentally or may be diagnosed on biopsy or excision. Oncocytomas have a classic gross appearance of a well-circumscribed tan or mahogany colored mass with a stellate central scar. Histologically they classically appear as well-circumscribed lesions with nested architecture, bland cytology, regular nuclei with prominent central nucleoli, and eosinophilic cytoplasm. Despite the classic appearance, there are several entities that mimic oncocytoma so diagnosis remains a challenge. Diagnosis is primarily made based on histologic appearance and, in challenging cases, with immunohistochemistry. Rarely cytogenetic studies may be useful. Renal oncocytomas usually have an excellent prognosis and are not associated with an aggressive clinical course; however, there can occasionally be metastasis to liver and bone and fatalities have occurred. Surgical excision is curative if there have not been metastases.ä |