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lüll Obesity Part I--Pathogenesis Bray GA; Gray DSWest J Med 1988[Oct]; 149 (4): 429-41Obesity--defined by a body mass index above 30 kg per m2--is a major problem for affluent nations. Its prevalence is higher in North America than in Europe--between 9% and 12% of the population. Reduced energy expenditure from exercise or metabolism or both may be an important contributory factor in the development of obesity because of a failure to reduce food intake sufficiently to maintain energy balance. A high ratio of abdominal circumference relative to gluteal circumference carries a twofold or greater risk of heart attack, stroke, hypertension, diabetes mellitus, gallbladder disease, and death. The effect of increased quantities of abdominal fat is greater than that of a similar increase in total body fat on the risks of ill health associated with obesity. Genetic factors appear to contribute about 25% to its etiology.|Adult[MESH]|Aged[MESH]|Anthropometry[MESH]|Body Composition[MESH]|Body Weight[MESH]|Energy Metabolism[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Obesity/complications/*etiology[MESH]|Risk Factors[MESH] |