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D-Pen2,L-Pen5 enkephalin induced analgesia in the jimpy mouse: in vivo evidence for delta-receptor mediated analgesia Mathiasen JR; Vaught JLEur J Pharmacol 1987[Apr]; 136 (3): 405-7Jimpy (B6CBA-A W-J/A-Ta jp) mice, which are known to be deficient in neuronal cerebroside sulfate (a putative component of the mu opioid receptor), were non-responsive in the tail flick test (compared to littermate controls and a standard Swiss strain of mouse) to analgesic doses of two mu opioid receptor agonists, morphine sulfate and [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO). However, the jimpy mice responded normally (compared to controls) to the analgesic effects of the selective delta opioid receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE). These results suggest (1) that delta opioid receptors can mediate analgesia and (2) that cerebroside sulfate is not necessary for delta opioid receptor activation.|*Analgesics[MESH]|Animals[MESH]|Cerebrosides/pharmacology[MESH]|Enkephalin, Ala(2)-MePhe(4)-Gly(5)-[MESH]|Enkephalin, D-Penicillamine (2,5)-[MESH]|Enkephalins/*pharmacology[MESH]|Injections, Intraventricular[MESH]|Male[MESH]|Mice[MESH]|Mice, Jimpy[MESH]|Morphine/pharmacology[MESH]|Reaction Time/drug effects[MESH]|Receptors, Opioid, delta[MESH]|Receptors, Opioid/*physiology[MESH] |
