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Molecular genetics of the human X chromosome Davies KEJ Med Genet 1985[Aug]; 22 (4): 243-9The human X chromosome will soon be mapped at 10 cM intervals. This will permit the localisation of any X linked disorder provided that informative families are available for linkage analysis. The location of RFLPs currently in use for clinical diagnosis is summarised. The next decade should witness the elucidation of the molecular basis of some of the more common defects, such as the muscular dystrophies and X linked mental retardation.|*DNA Restriction Enzymes[MESH]|*X Chromosome/ultrastructure[MESH]|Chromosome Mapping[MESH]|Fragile X Syndrome/genetics[MESH]|Genetic Diseases, Inborn/genetics[MESH]|Genetic Linkage[MESH]|Humans[MESH]|Intellectual Disability/genetics[MESH]|Muscular Dystrophies/genetics[MESH]|Plasmids[MESH]|Polymorphism, Genetic[MESH]|Sex Chromosome Aberrations/genetics/therapy[MESH]|Y Chromosome[MESH] |
