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lüll Traumatic Brain Injury and Alzheimer s Disease: The Cerebrovascular Link Ramos-Cejudo J; Wisniewski T; Marmar C; Zetterberg H; Blennow K; de Leon MJ; Fossati SEBioMedicine 2018[Feb]; 28 (ä): 21-30Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent a mechanistic link between Abeta/tau deposition after TBI and the development of post concussive syndrome, dementia and chronic traumatic encephalopathy (CTE). In addition to debilitating acute effects, TBI-induced neurovascular injuries accelerate amyloid beta (Abeta) production and perivascular accumulation, arterial stiffness, tau hyperphosphorylation and tau/Abeta-induced blood brain barrier damage, giving rise to a deleterious feed-forward loop. We postulate that TBI can initiate cerebrovascular pathology, which is causally involved in the development of multiple forms of neurodegeneration including AD-like dementias. In this review, we will explore how novel biomarkers, animal and human studies with a focus on cerebrovascular dysfunction are contributing to the understanding of the consequences of TBI on the development of AD-like pathology.|*Cerebrovascular Circulation[MESH]|Alzheimer Disease/*complications/pathology/*physiopathology[MESH]|Animals[MESH]|Blood-Brain Barrier/pathology[MESH]|Brain Injuries, Traumatic/*complications/pathology/*physiopathology[MESH]|Endothelial Cells/pathology[MESH]|Humans[MESH]|Mitochondria/metabolism[MESH] |