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lüll Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study Terrell TR; Abramson R; Barth JT; Bennett E; Cantu RC; Sloane R; Laskowitz DT; Erlanger DM; McKeag D; Nichols G; Valentine V; Galloway LBr J Sports Med 2018[Feb]; 52 (3): 192-198BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser(53)Pro, MAPT/tau Hist(47)Tyr, IL-6572 G/C and IL-6R(Asp)358(Ala) with the risk of concussion in college athletes. METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion. RESULTS: The study cohort consisted of 1056 athletes of mean+/-SD age 19.7+/-1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders. CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.|*Polymorphism, Genetic[MESH]|Adolescent[MESH]|Apolipoprotein E4/genetics[MESH]|Athletes[MESH]|Athletic Injuries/epidemiology/*genetics[MESH]|Brain Concussion/epidemiology/*genetics[MESH]|Female[MESH]|Gene Frequency[MESH]|Genotype[MESH]|Humans[MESH]|Male[MESH]|Prevalence[MESH]|Prospective Studies[MESH]|Receptors, Interleukin-6/genetics[MESH]|Students[MESH]|Universities[MESH]|Young Adult[MESH] |