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lüll The effect of theophylline and beta 2 agonists on airway reactivity Ahrens RC; Milavetz G; Joad JChest 1987[Jul]; 92 (1 Suppl): 15S-21SIncreased airway responsiveness occurs in asthma, chronic bronchitis, cystic fibrosis, and other diseases. Theophylline and beta 2 agonists commonly are used as maintenance therapy for symptoms associated with the increased responsiveness. Both drugs can reduce airway responsiveness to a variety of provocational stimuli. With currently used dosing regimens, theophylline appears to produce relatively constant levels of effect on airway responsiveness and clinical efficacy around the clock, while inhaled beta 2 agonists appear to have insufficient effects at the end of longer dosing intervals. Improved dosing strategies for beta 2 agonists may improve the efficacy of these agents in the future.|*Bronchial Provocation Tests[MESH]|Administration, Oral[MESH]|Adrenergic beta-Agonists/administration & dosage/*therapeutic use[MESH]|Adult[MESH]|Albuterol/administration & dosage[MESH]|Asthma/*drug therapy/physiopathology[MESH]|Clinical Trials as Topic[MESH]|Double-Blind Method[MESH]|Drug Evaluation[MESH]|Drug Therapy, Combination[MESH]|Forced Expiratory Volume[MESH]|Humans[MESH]|Respiratory Therapy[MESH]|Theophylline/administration & dosage/*therapeutic use[MESH] |