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lüll Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection Takino T; Okamura T; Ando T; Hagiwara KBMC Vet Res 2016[Nov]; 12 (1): 253BACKGROUND: Borna disease virus is a neurotropic pathogen and infects the central nervous system. This virus infected a variety of animal species including cows. The most of cows infected with Borna disease virus 1 (BoDV-1) exhibit subclinical infection without any neurological symptoms throughout their lifetime. We previously reported on the low conception rates in-seropositive cows. Interferon-tau (IFN-tau) plays an important role in stable fertilization, and is produced from the fetal side following embryo growth at 15-40 days of pregnancy. IFN-tau induces the expression of interferon-stimulated gene (ISG) 15 and Mx2 in peripheral blood mononuclear cells (PBMCs). To understand the embryo growth and maternal reaction during early pregnancy in cows with BoDV-1 infection, we aimed to assess the gene expression of ISG15 and Mx2 from PBMCs in BoDV-1-seropositive cows. RESULTS: None of the cows showed any clinical and neurological symptoms. Among the cows that conceived, the expressions of the ISG15 and Mx2 genes were greater in the BoDV-1-seropositive cows than in the BoDV-1-seronegative cows; the difference was significant between the cows that conceived and those that did not (P < 0.05). CONCLUSIONS: The expression of ISG15 and Mx2 genes during early pregnancy significantly increased in the BoDV-1-seropositive cows and may be important for the maintenance of stable pregnancy in BoDV-1-infected cows. In contrast, the gene expression levels of ISG15 and Mx2 did not significantly increase during early pregnancy in BoDV-1-seronegative cows. Thus, BoDV-1 infection may lead to instability in the maintenance of early pregnancy by interfering with INF-tau production.|Animals[MESH]|Antibodies, Viral/blood[MESH]|Borna Disease/*genetics/*immunology[MESH]|Borna disease virus/physiology[MESH]|Cattle[MESH]|Cattle Diseases/*genetics/*immunology[MESH]|Cytokines/*genetics[MESH]|Female[MESH]|Gene Expression Regulation/*immunology[MESH]|Interferons/metabolism[MESH]|Leukocytes, Mononuclear/metabolism[MESH]|Myxovirus Resistance Proteins/*genetics[MESH]|Pregnancy[MESH] |