Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection Kelly ML; Ng YK; Cartman ST; Collery MM; Cockayne A; Minton NPAnaerobe 2016[Jun]; 39 (ä): 51-3Comparative analysis of the Clostridium difficile BI/NAP1/027 strain R20291 and ClosTron-derived ermB mutants in the hamster infection model are compromised by the clindamycin susceptibility of the parent. Mutants can appear more virulent. We have rectified this anomaly by genome engineering. The variant created (CRG20291) represents an ideal control strain for virulence assays of ClosTron mutants.|*Disease Models, Animal[MESH]|*Genes, Synthetic[MESH]|*Genome, Bacterial[MESH]|Animals[MESH]|Anti-Bacterial Agents/pharmacology[MESH]|Clindamycin/pharmacology[MESH]|Clostridioides difficile/drug effects/*genetics/pathogenicity[MESH]|Cricetulus/*genetics/microbiology[MESH]|Enterocolitis, Pseudomembranous/drug therapy/*microbiology/mortality/pathology[MESH]|Gene Expression[MESH]|Genetic Engineering[MESH]|Humans[MESH]|Methyltransferases/*genetics[MESH]|Microbial Sensitivity Tests[MESH]|Mutation[MESH]|Survival Analysis[MESH]|Virulence[MESH] |