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lüll Myelodysplastic syndromes Doll DC; List AFWest J Med 1989[Aug]; 151 (2): 161-7The myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders characterized by dysplastic and ineffective hematopoiesis and a varying risk of transformation to acute leukemia. Although the natural history of these syndromes is variable, several factors appear to be of prognostic importance, including the French-American-British classification, the karyotype, in vitro colony formation, and others. The pathogenesis of the myelodysplastic syndrome is not known, but recent evidence suggests that alterations of cellular oncogenes may be a causative factor. There is no standard therapy for myelodysplasia, and thus novel approaches to patient management are warranted.|*Myelodysplastic Syndromes/classification/diagnosis/genetics[MESH]|Aged[MESH]|Humans[MESH]|Prognosis[MESH] |