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lüll Chronic cutaneous graft-versus-host disease in man Shulman HM; Sale GE; Lerner KG; Barker EA; Weiden PL; Sullivan K; Gallucci B; Thomas ED; Storb RAm J Pathol 1978[Jun]; 91 (3): 545-70This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute GVHD; in 8 it occurred after the resolution of acute GVHD; and in 5 it arose without preceding acute GVHD, ie, de novo late onset. Two cutaneous types were distinguished. The generalized type affected 16 patients and ran a progressive course resulting in late complications of poikiloderma, diffuse dermal and subcutaneous fibrosis, and contractures. Microscopically, it resembled generalized morphea and lupus erythermatosus hypertrophicus et profundus. The local type affected 3 patients with a more variable picture of poikiloderma, dermal sclerosis, and contractures. Microscopically, it resembled lupus of erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD are proposed.|*Bone Marrow Transplantation[MESH]|*Skin Manifestations[MESH]|Adolescent[MESH]|Adult[MESH]|Child[MESH]|Child, Preschool[MESH]|Chronic Disease[MESH]|Contracture/etiology[MESH]|Female[MESH]|Graft vs Host Disease/*pathology[MESH]|Graft vs Host Reaction[MESH]|Humans[MESH]|Male[MESH]|Neurologic Manifestations[MESH]|Oral Manifestations[MESH]|Sialadenitis/etiology[MESH]|Skin/*pathology[MESH]|Transplantation, Homologous/*adverse effects[MESH] |