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Learning deficiencies in Borna disease virus-infected but clinically healthy rats Dittrich W; Bode L; Ludwig H; Kao M; Schneider KBiol Psychiatry 1989[Dec]; 26 (8): 818-28Borna disease (BD) virus, a still unclassified neurotropic agent, causes either fatal encephalomyelitis or persistent asymptomatic infection in a variety of animal species. We monitored the neuronal functions of intracerebrally infected but healthy rats with three types of learning experiments. Spatial discrimination learning, using the y maze and the hole board, was significantly less successful in BD virus-infected (I) compared with mock-infected (M) rats. Similarly, I rats tended to show a certain emotional disturbance (reduced resting behavior and less anxiety) as evaluated by open-field and neophobia tests. Furthermore, in two aversive learning experiments (taste aversion and reaction suppression via Skinner box), it appeared that the I rats expressed a significantly diminished ability to learn pain avoidance compared with M rats. In conclusion, we found specific learning deficiencies together with subtle behavioral alterations suggesting that BD virus causes certain modulations of high integrative brain functions which are only detectable under experimental conditions.|Animals[MESH]|Arousal/physiology[MESH]|Attention/physiology[MESH]|Avoidance Learning/physiology[MESH]|Borna Disease/*physiopathology[MESH]|Borna disease virus/*pathogenicity[MESH]|Brain/microbiology[MESH]|Discrimination Learning/physiology[MESH]|Disease Models, Animal[MESH]|Learning Disabilities/*physiopathology[MESH]|Neurocognitive Disorders/*physiopathology[MESH]|Orientation/physiology[MESH]|Rats[MESH]|Rats, Inbred Strains[MESH]|Taste/physiology[MESH]|Viruses, Unclassified/*pathogenicity[MESH] |
