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lüll Use of diffusion-weighted, intravoxel incoherent motion, and dynamic contrast-enhanced MR imaging in the assessment of response to radiotherapy of lytic bone metastases from breast cancer Gaeta M; Benedetto C; Minutoli F; D'Angelo T; Amato E; Mazziotti S; Racchiusa S; Mormina E; Blandino A; Pergolizzi SAcad Radiol 2014[Oct]; 21 (10): 1286-93RATIONALE AND OBJECTIVES: To investigate the value of diffusion-weighted (DW), perfusion-sensitive, and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) techniques in assessing the response of bone metastases from breast cancer to radiotherapy, with particular emphasis on the role of intravoxel incoherent motion (IVIM)-DW parameters as a potential valuable imaging marker of tumor response. MATERIALS AND METHODS: Fifteen women having breast cancer and bone metastases underwent MRI before and after radiotherapy (3 weeks [time 1], 2 months [time 2], and 4 months [time 3]), consisting of DW, perfusion-sensitive (IVIM), and DCE acquisitions. MR-based DW and perfusion parameters, including water diffusivity (D), perfusion fraction (f), pseudodiffusion (D*), total apparent diffusion coefficient (ADC-total), fractionated ADCs (ADC-high and ADC-low), and initial area under the gadolinium concentration curve after the first 60 seconds (IAUGC60), were determined. The morphologic MRI findings were also recorded. A one-way repeated measures analysis of variance was used to compare the value of MR-based parameters at the different time points. RESULTS: A significant variation between pretreatment (time 0) and post-treatment (times 1, 2, and 3) was found for ADC-total and D parameters (P < .001). A statistically significant reduction was also found for IAUGC60 values between times 0 and 3 (P < .001). A significant change across the different time points was observed for D* and IAUGC60 parameters (P < .001). On the contrary, there was no statistically significant change over time for parameters ADC-total, D, f, and IAUGC60 comparing response between each metastasis, that is, the response to therapy was similar for each metastasis. CONCLUSIONS: DW, IVIM, and DCE-MRI techniques show effectiveness in assessing the response to radiotherapy in bone metastases from breast cancer.|*Artifacts[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Algorithms[MESH]|Bone Neoplasms/pathology/*radiotherapy/*secondary[MESH]|Breast Neoplasms/*pathology/radiotherapy[MESH]|Contrast Media[MESH]|Diffusion Magnetic Resonance Imaging/*methods[MESH]|Female[MESH]|Humans[MESH]|Image Enhancement/*methods[MESH]|Imaging, Three-Dimensional/methods[MESH]|Magnetic Resonance Imaging/*methods[MESH]|Motion[MESH]|Outcome Assessment, Health Care/methods[MESH]|Prognosis[MESH]|Reproducibility of Results[MESH]|Sensitivity and Specificity[MESH]|Technetium Tc 99m Medronate[MESH]|Treatment Outcome[MESH] |