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Clinicopathological characteristics of laterally spreading colorectal tumor Zhao X; Zhan Q; Xiang L; Wang Y; Wang X; Li A; Liu SPLoS One 2014[]; 9 (4): e94552BACKGROUND AND AIMS: Laterally spreading tumor (LST) is a colorectal pre-cancerous lesion. Previous studies have demonstrated distinct LST clinicopathological characteristics in different populations. This study evaluated clinicopathological characteristics of LST in a Chinese population. METHODS: A total of 259 Chinese LST patients with 289 lesions were recruited for endoscopic and clinicopathological analyses. RESULTS: Among these 289 lesions, 185 were granular type (LST-G), whereas 104 were non-granular type (LST-NG). LST-G lesions were further classified into homogeneous G-type and nodular mixed G-type, while LST-NG lesions were further classified into flat elevated NG-type and pseudo-depressed NG-type. Clinically, these four LST subtypes showed distinct clinicopathological characteristics, e.g., lesion size, location, or histopathological features (high-grade intraepithelial neoplasia and submucosal carcinoma). The nodular mixed G-type showed larger tumor size and higher incidence of high-grade intraepithelial neoplasia compared to the other three subtypes, while pseudo-depressed NG-type lesions showed the highest incidence of submucosal carcinoma. Noticeably, no diffidence was detected between the lesions of homogeneous G-type and flat elevated NG-type with regard to the histopathological features. Histology of the malignancy potential was associated with nodular mixed G-type [OR = 2.41, 95% CI (1.09-5.29); P = 0.029], flat elevated NG-type [OR = 3.49, 95% CI (1.41-8.22); P = 0.007], Diameter >/=30 mm [OR = 2.56, 95% CI (1.20-5.20); P = 0.009], Villous adenoma [OR = 2.76, 95% CI (1.01-7.58); P = 0.048] and serrated adenoma [OR = 6.99, 95% CI (1.81-26.98); P = 0.005]. CONCLUSION: Chinese LSTs can be divided into four different subtypes, which show distinct clinicopathological characteristics. Morphology, size and pathological characteristics are all independent predictors of advanced histology.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Colonoscopy[MESH]|Colorectal Neoplasms/diagnosis/*pathology[MESH]|Demography[MESH]|Female[MESH]|Humans[MESH]|Intestinal Mucosa/pathology[MESH]|Logistic Models[MESH]|Male[MESH]|Middle Aged[MESH]|Multivariate Analysis[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Staging[MESH]|Staining and Labeling[MESH] |
