Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Current and future molecular diagnostics in colorectal cancer and colorectal adenoma Tsang AH; Cheng KH; Wong AS; Ng SS; Ma BB; Chan CM; Tsui NB; Chan LW; Yung BY; Wong SCWorld J Gastroenterol 2014[Apr]; 20 (14): 3847-57Colorectal cancer (CRC) is one of the most prevalent cancers in developed countries. On the other hand, CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy. Since CRC develops slowly from precancerous lesions, early detection can reduce both the incidence and mortality of the disease. Fecal occult blood test is a widely used non-invasive screening tool for CRC. Although fecal occult blood test is simple and cost-effective in screening CRC, there is room for improvement in terms of the accuracy of the test. Genetic dysregulations have been found to play an important role in CRC development. With better understanding of the molecular basis of CRC, there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC. In this review, the molecular basis of CRC development, the characteristics and applications of different non-invasive molecular biomarkers, as well as the technologies available for the detection were discussed. This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state, colorectal adenoma.|Adenoma/*diagnosis/*genetics[MESH]|Biomarkers, Tumor/*metabolism[MESH]|Colorectal Neoplasms/*diagnosis/epidemiology/*genetics[MESH]|Cost-Benefit Analysis[MESH]|DNA, Neoplasm/metabolism[MESH]|Epigenesis, Genetic[MESH]|Feces[MESH]|Gene Silencing[MESH]|Humans[MESH]|MicroRNAs/metabolism[MESH]|Microsatellite Instability[MESH]|Occult Blood[MESH]|Pathology, Molecular/methods/trends[MESH]|Reproducibility of Results[MESH] |